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Position Overview:
The Khanna lab seeking a skilled Slice Electrophysiologist to join our neuroscience research team focused on chronic pain mechanisms. This role involves conducting spinal cord-level investigations using acute slice preparations to elucidate pain signaling pathways, evaluate novel therapeutic targets, and assess the efficacy of emerging drugs. The position is ideal for a detail-oriented scientist passionate about translational pain research in a collaborative academic or pharmaceutical environment.
Job Duties:
- Prepare and maintain acute spinal cord slices from rodent models of chronic pain (e.g., neuropathic or inflammatory models).
- Perform patch-clamp electrophysiology recordings to investigate neuronal excitability, synaptic transmission, and ion channel function in spinal cord dorsal horn neurons.
- Evaluate novel molecular targets (e.g., ion channels, receptors) and test candidate drugs for their impact on pain-related plasticity and hypersensitivity.
- Analyze electrophysiological data using software such as pCLAMP, Igor Pro, or MATLAB to quantify changes in membrane properties, action potentials, and synaptic currents.
- Collaborate with multidisciplinary teams to integrate findings with behavioral, molecular, and imaging studies.
- Maintain detailed experimental records, contribute to manuscript preparation, and present results at lab meetings and conferences.
- Perform surgical procedures.
- Aid in the supervision of technicians, undergraduate students, and graduate student
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